Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.
Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications.A negative association of adiponectin levels with breast cancer development has been demonstrated.However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive.In the present study, MMTV-polyomavirus middle T antigen (M