ADIPONECTIN HAPLOINSUFFICIENCY PROMOTES MAMMARY TUMOR DEVELOPMENT IN MMTV-PYVT MICE BY MODULATION OF PHOSPHATASE AND TENSIN HOMOLOG ACTIVITIES.

Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities.

Adiponectin is an adipokine possessing beneficial effects on obesity-related medical complications.A negative association of adiponectin levels with breast cancer development has been demonstrated.However, the precise role of adiponectin deficiency in mammary carcinogenesis remains elusive.In the present study, MMTV-polyomavirus middle T antigen (M

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